Victory at the Amex will see Pep Guardiola’s men become the first side to retain the title in a decade
Manchester City handed Riyad Mahrez a start ahead of Leroy Sane at Brighton as the Citizens close in on the Premier League title.
And the defending champions are buoyed by the return of Kevin De Bruyne, with the Belgium international making his injury comeback and earning a place on the bench.
Pep Guardiola’s men have been on a blistering run and know a 14th straight victory will see them crowned champions once again.
Should City win at the Amex, then Liverpool’s result against Wolves at Anfield will be irrelevant given they are already a point ahead before the start of play.
The last time a side was able to retain the Premier League trophy was when Sir Alex Ferguson managed it with rivals United in 2008 and 2009.
After Liverpool’s late win against Newcastle on Saturday night, City responded perfectly at home to Leicester courtesy of a stunning strike from Vincent Kompany.
Here’s how the teams line up on the south coast.
Brighton XI: Ryan, Bruno (C), Duffy, Dunk, Bernardo, Knockaert, Kayal, Bissouma, Jahanbakhsh, Gross, Murray
Subs: Button, Burn, Bong, Montoya, Mulumby, Locaadia, Andone
Man City XI: Ederson, Walker, Kompany (C), Laporte, Zinchenko, Gundogan, Silva, Mahrez, Sterling, Bernardo, Aguero
Subs: Muric, Danilo, Stones, De Bruyne, Sané, Otamendi, Jesus